Publications
Balancing Issues: measuring and treating vestibular dysfunction and sensory reweighting (not peer-reviewed)
Declining balance and mobility, clinically known as “presbystasis,” is one of the most visible, debilitating, and costly signs of aging. Presbystasis significantly increases the risk of falls and hinders the ability to live actively, independently, and productively. Despite the prodigious implications of balance decline in geriatric care, targeted non-surgical interventions are lacking.
Moreover, quantitative measurements for clinically evaluating balance and mobility parameters (i.e., functional biomarkers) require specialized laboratory equipment or rely on subjective, inconsistent, and outdated methods.
Our client, Neursantys, offers innovative, noninvasive, cost-effective, quantitative, award-winning, and simple solutions for both diagnosing and treating balance dysfunction.
Geocyte collaborated with Neursantys Co-Founder and CEO John Ralston on an article ("Balancing Issues") for the Winter 2025 issue of Today's Geriatric Medicine about how "Phybrata" (the diagnostic) and "Neurvesta" (the therapy) wearable technologies are addressing unmet needs in fall prevention. The article made the cover, just not the cover picture.
Microbiome & Metabolism
Geoff's dog, Patton (RIP), eating Hill's Pet Science Diet to stay nourished and active while backpacking in Wyoming's Bridger-Teton wilderness, August 2014
"Food as medicine" polyphenol-rich plant fibers impart health benefits in companion animals and people! In this clinical canine study, we used metabolomics and microbiome sequencing to show how a novel prebiotic fiber bundle uniquely improves pathway markers of gastrointestinal and systemic host health, particularly through promoting saccharolytic and suppressing putrefactive microbial metabolism, while generating beneficial fecal postbiotics and circulating anti-inflammatory signatures.
Chronic large-bowel diarrhea is a common occurrence in pet dogs. While nutritional intervention is considered the primary therapy, the metabolic and gut microfloral effects of fiber and polyphenol-enriched therapeutic foods are poorly understood.
This prospective clinical study enrolled 31 adult dogs with chronic, active large bowel diarrhea from private veterinary practices. Enrolled dogs received a complete and balanced dry therapeutic food containing a proprietary fiber bundle for 56 days. Metagenomic and metabolomic profiling were performed on fecal samples at Days 1, 2, 3, 14, 28, and 56; metabolomic analysis was conducted on serum samples taken at Days 1, 2, 3, 28, and 56.
In dogs with chronic diarrhea, feeding specific dietary fibers increased gut saccharolysis and bioavailable phenolic and indole-related compounds while suppressing putrefaction. These changes were associated with improved markers of gut inflammation and stool quality.
Part of the efficacy of the gut microbiome "activation" described in this video for Activbiome+ prebiotic in companion animals is a shift away from undesirable proteolytic bacterial activity towards more beneficial saccharolytic metabolism, as described in these two manuscripts.
White Papers
"Beyond Blood" sample types for proteomics
Dried blood spots & microsampling
Alamar Biosciences' NULISA platform can extract high-quality proteomics data from the lowest abundant proteins in minimum sample volumes, making it the ideal technology for analyzing capillary blood samples collected using microsampling devices, including:
- dried blood spot (DBS)
- quantitative DBS (qDBS)
- dried plasma spot (DPS)
Alternative sample types
Blood-based samples aren't the only matrices containing useful proteomic biomarker data. "Closer to the phenotype" and less invasive to collect, alternative sample types can support self-collection and longitudinal study design. Collaborators at Alamar Biosciences who are pioneering the use of these samples were profiled, as well as the detectability of sample types and their biological signatures.
Spatial multi-omics sample prep automation
Akoya PhenoCycler Fusion automated method validation
Akoya's PhenoCycler Fusion (PCF, formally CODEX) proteomics platform enables high-plex imaging of the tumor microenvironment and other tissue biospecimens at sub-cellular resolution. Spatial biology pioneers and subject-matter experts collaborated to automate the PCF assay on Parhelia's new purpose-built automation system, the Spatial Station (note: Geocyte also did all Parhelia's website content).
This white paper was written as a research article to showcase the utility of the Spatial Station instrument in a high-value application while demonstrating a popular spatial 'omics workflow example.
Spatial 'omics sample prep reagents and kits evaluation
Parhelia markets single-use, all-in-one Skylab Kits for dewaxing+antigen retrieval and dewaxing+hematoxylin-eosin staining for scaling sample prep on the Spatial Station (note: Geocyte also did all Parhelia's website content).
This white paper was written as a research article to showcase how the dewaxing reagent, retrieval buffers, and kits stack up against the status quo manual staining and reagents.
Artificial intelligence & machine-learning (AI/ML) for rapid metabolite annotation and accurate quantitation
Matterworks developed an innovative large spectal model (LSM, akin to a Large Language Model, LLM) from metabolomic mass spectrometry data. Their first product is Pyxis, an advanced machine-learning, cloud-based software and reagent kit that enables the rapid identification and accurate quantitation of metabolites in raw mass spec data. With Pyxis, researchers don't need to procure expensive authentic standards and run them with demanding analytical chemistry techniques; they use Pyxis.
Pyxis AI/ML for biprocessing & cell culture
Bioprocessing and other cell culture analysis applications are the primary markets for Pyxis. Geocyte wrote this white paper to showcase the utility of Pyxis in interpreting rapid metabolic profiling data in a CHO cell bioprocess.
Pyxis AI/ML in multiple sample matrices
Geocyte wrote this white paper in Chemical & Engineering News with the Matterworks science team to describe how Pyxis is widely applicable in multiple sample types.
Biospecimens for precision and translational medicine
Clinical trials usually proceed in a prospective manner, where specimens and data are gathered as the trial unfolds. Thanks to Sanguine's direct-to-patient approach, researchers can prospectively design discovery, translational, and supplemental clinical studies and obtain annotated human biospecimens from patients and healthy donors just as you would a clinical trial.
This white paper was designed to read like a comprehensive review describing how the prospective collection of biospecimens aligns with precision medicine principles.
Immunotherapy sample prep automation for flow cytometry
Scientists from Charles River Laboratories and Curiox Biosystems collaborated to characterize the performance and workflow of Laminar WashTM systems in isolating and preparing tumor-infiltrating leukocytes (TILs) from anti-PD1-challenged CT26 mice as a model system.
This white paper was written in the style of a research article to showcase the utility of the Laminar Wash technology in a high-value application, immunotherapy research sample preparation, and provide potential customers with a flow cytometry workflow example.
High quality data begins with high quality sample preparation. Designed to encourage researchers conducting single-cell genomics experiments, this white paper aims to convince sample prep reproducibility and automation should be considered in obtaining the highest quality data, using published and webinar-presented examples.
Before starting Geocyte, Geoff worked at Curiox. He conceptualized, outlined, instructed the primary literature material, generated the graphics, and edited this white paper, which was written by a contractor through Fierce Biotech.
Publications: Structural Biology
Read about Geoff's publications from when he was a biophysical chemistry student and postdoc at our Structural Biology Applications page, including:
- Anthrax toxin and protein translocation structure and function
- Biology with X-ray lasers (i.e., blowing up tiny crystals with femtosecond free-electron lasers, pew pew pew!)
- Virulence factors from the biothreat agent Francisella tularensis
